REQUEST FOR PROPOSALS
The Harvard University Center For AIDS Research announces the following dates regarding the upcoming release of Request For Proposals for HIV/AIDS-related research:
DOWNLOAD THE RFP
| Upcoming Dates (Estimated) | |
| Next RFP To Be Posted: | Early September 2008 |
| Submit Applications: | Early November 2008 |
| Application Review: | December 2008 |
Application Notification: |
Late December 2008 |
Projected Start date: |
January 1, 2009 |
IMPORTANT CHANGE TO APPLICATION PROCESS FOR UPCOMING RFP CYCLE: New to this RFP cycle: Awarded proposals will require institutional approval prior to release of funds. It is recommended that you turn your application in to your respective institution's Research Administration for review two weeks before the application is due to the CFAR. There will be only one RFP for the 2007-2008 academic year. The next RFP will be released in the fall of 2008. |
Prerequisites to Beginning Work for CFAR RFP Awardees
AWARDS
In January 2008, the HU CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
Role of TNPO3 in HIV Infection |
Brass, Abraham L. |
BWH |
The Association among social environments, individuals behaviours, and the incidence and prevalence of HIV/AIDS in women in sub-Saharan Africa |
Ghebremichael, Musie |
DFCI |
Patient and site factors associated with quality of care and outcomes, Tanzania |
Hirschhorn, Lisa |
HMS Division of AIDS |
SIV/AIDS and structural variation in the macaque genome |
Johnson, Welkin E. |
NEPRC |
A study of the safety of coretrimoxizoleprophylaxis in HIV and HAART-exposed infants in Botswana |
Lockman, Shahin |
Botswana Harvard School of Public Health AIDS Partnership (BHP), Gabarone, Botswana |
Inhaled kanamycin: A new approach for reducing TB transmission to AIDS patients |
Nardell, Edward |
BWH |
Trafficking and HIV risk among HIV-infected commercial sex workers |
Silverman, Jay |
HSPH |
Visualizing the Immune System–HIV Interface by Multiphoton Intravital Microscopy |
Tagar, Andrew M. |
MGH |
Incidence of Myocardial Infarction and Cardiovascular Risk Factors in an HIV-Infected Population |
Traint, Virginia Athena |
MGH |
In July 2007, the HU CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| Linkage and Loss: Long-Term Outcome of HIV Testing in Durban, South Africa | Bassett, Ingrid; Giddy, Janet; Losina, Elena; Ross, Douglas; Freedberg, Kenneth; Holst, Helga; Regan, Sue; Walensky, Rochelle | MGH; McCord Hospital SA; BWH; St. Mary's Hospital SA |
| Impulsivity and risk behavior in HIV and cocaine dependence: an fMRI pilot study | Meade, Christina; Safren, Steve; Lukas, Scott; Renshaw, Perry; Frederick, Blaise | McLean Hopsital, MGH |
| Improving Strategies for TB Diagnosis and Prophylaxis in South Africa | Bender, Melissa Amy; Freedberg, Kenneth A.; Horsburgh, C. Robert; Wood, Robin | MGH |
| The role of Mycobacterium Tuberculosis induced NFAT5 in HIV-1 replication | Ranjbar, Shahin; Goldfeld, Anne | CBR |
| The role of human Staufen in the intracellular trafficking of unspliced HIV RNA | Lieberman, Judy; Yan, Nan | CBR |
| Development of a low-cost HIV viral load device for resource-limited settings | Rodriguez, William; Manalis, Scott; Toner, Mehmet; Chen, Grace | BIDMCMGH; Department of Biological and Mechanical Engineering, MIT, Cambridge, MA |
| The study of the role of Follicular Dendritic Cells in trapping HIC | Zhao, Xiaomin; Fingeroth, Joyce; Kutok, Jeff; Rheinwald, James; Gabuzda, Helga | BIDMC |
| Targeting Enfuvirtide Resistence in HIV with Hydrocarbon-Stapled Fusion Helices | Bird, Gregory | DFCI |
In January 2007, the HU CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| "Prevalence and Risk Factors for HIV Among South Asian Sex Trafficking Victims" | Silverman, Jay; Seage, George; Raj, Anita | HSPH, BU |
| "Etiology and clinical features of pneumonia in HIV-infected and HIV-uninfected infants born to HIV-infected women, Botswana" | Lockman, Shahin; McAdam, Alexander; McIntosh, Kenneth; Wester, Carolyn | CHB: BWH; HSPH; Botswana BHP |
| "Genital Tract HIV-1 and HAART: Does HSV-2 Play a Role?" | Wester, Carolyn; Essex, Max; Notitsky, Vladimir | HSPH;Botswana BHP; Infectious Diseases Care Clinic (IDCC) at Princess Marina Hospital, Gaborone, Botswana |
| "Characterization of heterologous neutralizing antibodies in HIV-2" | Sarr, Abdoulaye Dieng; Mullins, Christopher | HSPH |
| "Clinical Significance of Minor Variant Resistance After Single-Dose Nevirapene" | Rowley, Christopher; Essex, Max; Lockman, Shahin | HSPH; BWH |
| "Structural Basis for Cyclin T1 Interaction with HIV-1 tat and TAR" | Ladias, John A.A.; Birranne, Gabriel; Gu, Lina | BIDMC |
| "An RNA Interference Strategy for Identifying Host Factors Required for HIV Infection" | Elledge, Stephen J.; Lieberman, Judy; Brass, Abraham L.; Dykxhoorn, Derek | BWH; CBR; Institue of Chemistry and Cell Biology - Longwood (ICCB-L) - Boston |
| "HIV-1 Tropism in Subtype C-Infected Patients from KwaZulu Natal" | Kuritzkes, Dan; Ndung'u, Thumbi; Sunpath, Henry; Murphy, Richard | BWH: Doris Duke Medical Research Institute University of KwaZulu-Natal, South Africa; McCord Hospital South Africa |
| "Risk Factors for the Development of NVP-Associated Toxicity in Southern Africa" | Wester, C. William; De Gruttola, Victor; Essex, Max; Kuritzkes, Dan; Marlink, Richard; Novitsky, Vladimir; O'Brien, Stephen A.; Thomas, Ann Muir | HSPH;Botswana BHP; NCI |
| "Effect of dietary fat on systemmic inflammation: implications for SIV progression" | Wachtman, Lynn M.; Mansfield, Keith G. | NEPRC |
| "Role of PD-1 in immunological synapse formation and T cell function" | Ahmed, Fariyal; Lieberman, Judy | CBR |
In July 2006, the HU CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| NK cell function in HIV-1-infected individuals from KwaZulu Natal | Altfeld, Marcus; Wilson, Douglas, Kiepiela, Photini | MGH; Edendale; U of KwaZulu Natal |
| Evaluation of football-based HIV education on KZN | Deutsch, Charles; Ojikutu, Bisola | HSPH / HMS / Kwa Zulu Natal, SA |
| Targeting capsid dimerization for inhibition of HIV assembly (2nd year of funding) | Ivanov, Dmitri; Wagner, Gerhard; Engelman, Alan | HMS / DFCI |
| Targeting anti-HIV siRNA to T cells in Hu/PBL reconstituted NOD/SCIDIL2yc mice | Kumar, Priti; Shankar, Premlata | CBR |
| Assessment of anitgen processing mutations in flanking regions of HIV epitopes (2nd year of funding) View the Related Publication |
LeGall, Sylvie; Allen, Todd; Altfeld, Marcus | MGH |
| Structure/function relationship studies on isotype-switched IgA antibodies to HIV | Miranda, Luis; Cavacini, Lisa | BIDMC |
| Bacterial expression of anti-HIV antibodies for microbicide use | Posner, Marshall; Cavacini, Lisa; Horwitz, Marc; Smit, John | BIDMC / Univ of British Columbia |
In January 2006, the HMS CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| HIV prevention for women: Barriers, facilitators, and the media's role | Arya, Monisha; Viswanath, Kasisomayajula; Stone, Valerie; Behforouz; Lee, Sandra | BIDMC / HSPH / HMS |
| Presentation of HIV lipopeptide anitgens to CD1-retricted T cells | de Jong, Annemieke; Moody, Branch; Katz, Joel; Ruprecht, Ruth; Young, David | DFCI / BWH |
| Risk factors for lactic acidosis in an ART cohort in KwaZulu-Natal, SA | Hurtado, Rocio; Murray, Megan; Wallengren, Kristina; Wilson, Douglas; Dong, Krista | MGH / BWH / HMS / HSPH / Edendale Hospital (SA) |
| Development of a MEMS-based CD4 counting device for resource-limited settings | Rodriguez, William; Demirci, Utkan; Irimia, Daniel; Toner, Mehmet | MGH |
| TCR sequence of HIV-1-specific CD8+ T cells: Impact on viral escape | Yu, Xu | MGH |
| Cellular and molecular mechanisms of HIV infection in humanized mice | Yang, Yong-Guang; Sykes, Megan; Walker, Bruce; Hongo, David | MGH |
| Ultra-deep sequencing of the V3 loop in patients failing CCR5 inhibitor therapy | Tsibris, Athe; Nussbaum, Chad; Kuritzkes, Dan | MGH / Broad Institute / BWH |
In July 2005, the HMS CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| Characterization of T regulatory cells in HIV/HCV co-infected subjects | Alatrakchi, Nadia; Koziel, Margaret | BIDMC |
| Long-term cost effectiveness of an HIV adherence program | Behforouz, Heidi; Zheng, Hui; Freedberg, Ken; Weinstein, Milton | MGH / BWH |
| Targeting capsid dimerization for inhibition of HIV assembly | Ivanov, Dmitri; Wagner, Gerhard; Engelman, Alan | CHB / HMS / DFCI |
| Role of HIV-specific CD4 cells in control of viremia after primary HIV infection | Kaufmann, Daniel; Rosenberg, Eric | MGH |
| Assessment of antigen processing mutations in flanking regions of HIV epitopes View the Related Publication |
Le Gall, Sylvie; Allen, Todd; Altfeld, Marcus | MGH |
| Maximizing the benefits of the Massachusetts AIDS drug resistance assistance program | Linas, Benjamin; Freedberg, Ken; Losina, Elena; Walensky, Rochelle; Zheng, Hui | MGH/ Boston University School of Public Health |
| Transmission of MDR-TB from HIV and non-HIV infected hospitalized patients | Nardell, Edward; Weyer, Karin | BWH / MRC |
| HIV-1 envelope variable loops ViV2 influence on viral entry | Sagar, Manish; Anderson, Deborah; Kuritzkes, Daniel; Pudney, Jeffrey | BWH / BU |
| Entry inhibitor for gene therapy of SIV infection | Schmitz, Joern; Johnson, Paul; Caville, Angela; Von Laer, Dorothee | BIDMC / NEPRC/ Georg-Spyer-Haus |
In January 2005, the HMS CFAR and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| Natural killer cells in HIV-1 infection | Alter, Galit; Altfeld, Marcus; Walker, Bruce | MGH |
| The yield of opt out HIV testing in Durban, South Africa View the Related Publication |
Bassett, Ingrid; Freedberg, Ken; Giddy, Janet; Walensky, Rochelle; Walker, Bruce | MGH/HMS/McCord Hospital |
| SIV-based lentiviral vectors to inhibit SHIVS with RNA1 | Braun, Stephen; Johnson, Paul | HMS NEPRC |
| Effect of SIV gp120 on macrophage mycobacteriocidal | Hendricks, Elizabeth; Mansfield, Keith | HMS NEPRC |
| Optimizing OI prophylaxis and ART in South Africa | Holmes, Charles; Freedberg, Ken; Zheng, Hui | MGH |
| Evaluation of HIV related stigma in central Haiti | Ivers, Louise; Freedberg, Ken; Farmer, Paul | BWH |
| Prevalence of HIV resistance and outcomes of HAART in South Africa | Kuritzkes, Daniel; Marconi, Vincent; Sunpath, Henry; Gordon, Michelle; Khumalo, Nofuthula; Ross, Douglas; Smganie Dube, Lorraine; Walker, Bruce; Zheng, Hui | BWH/MGH/McCord Hospital/St. Mary's Hospital/Africa Centre Lab, DDMRI |
| Routine HIV testing in a Massachuetts prison | Liddicoat, Rebecca; Freedberg, Ken; Walensky, Rochelle | MGH |
| Perinatal outcomes and novel HIV assessment in infants | Mukherjee, Joia; Farmer, Paul; Ivers, Louise; Jerome, Jean-Gregory; Leandre, Fernet; Mann, Julie; Smith-Fawzi, Mary | BWH/Partners in Health |
| Harnessing RNA interference as an HIV microbicide | Palliser, Deborah; Lieberman, Judy | CBR |
| Regulation of Asian and African HIV-1 isolated by MTb | Ranjbar, Shahin; Shankar, Premalata; Rajsbaum, Ricardo; Goldfeld, Anne | CBR |
| Therapy of HIV-related anal dysplasia | Schlecht, Hans; Dezube, Bruce; Panther, Lori | BIDMC |
| Regulation of CTL trafficking in HIV infection | Tager, Andrew; Luster, Andrew | MGH |
| Genotypic resistance after pregnancy-limited combination antiretroviral therapy | Tuomala, Ruth; Kuritzkes, Daniel; Paredes, Roger | BWH |
In December 2003, the DFCI/BIDMC/CH CFAR, Partners/Fenway/Shattuck and HMS DAIDS awarded the following Feasibility Projects and Scholar Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| Pathogenicity of SIV Variants that Escape CTL Responses (request for second year of funding) | Barouch, Dan | BIDMC |
| GB-Virus-C Coinfection in HIV-1 infected individuals | Addo, Marylyn; Walker Bruce | MGH |
| Virology and Immunology in HIV Treatment Interruption | Altfeld, Marcus; Burgers, Wendy | MGH / University of Cape Town |
| Gene Therapy for AIDS using RNAi to inhibit SHIVs | Braun, Steve; Johnson Paul | NERPRC |
| Pathogenesis of HIV-HCV co-infection (request for second year of funding) | Chung, Raymond; Blackard, Jason | MGH |
| Effect of HIV infection on CXCR3 Expression and Function | Colvin, Richard; Luster Andrew | MGH |
| Feasibility of Collaborative HIV/Tuberculosis Treatment in Vietnam | Krakauer, Eric; Cosimi, Lisa; Sy, Dinh Ngoc; Rodriguez, William | HMS / BWH / National TB Program of Vietnam / NICRTM (Vietnam) |
| 7T MR Spectroscopy of SIV Infected CD8 Depleted Macaques | Ratai, Eva-Maria; Gonzalez, R. Gilberto; Masliah, Eliezer, Westmoreland, Susan; Williams, Kenneth | MGH/ UCSD / NERPRC / BIDMC |
| Candida virulence gene identification using C. elegans | Sifri, Costi; Calderwood, Stephen; Ausubel, Frederick; Fishman, Jay | MGH |
In February 2003, the DFCI/BIDMC/CH CFAR, Partners/Fenway/Shattuck and HMS DAIDS awarded the following Pilot Awards:
| Project Title | Investigators | Institution |
|---|---|---|
| Pathogenicity of SIV variants that escape CTL responses | Barouch, Dan | BIDMC |
| Immunopathogenesis of HIV-HCV Co-infection | Chung, Raymond; Blackard, Jason; | MGH |
| C neoformans: identification of novel virulence factors | Mylonakis, Eleftherios; Enloe, Brian; Calderwood, Stephen; Ausubel, Frederick | MGH |
| HIV vaccines in TH2 biased recipients | Essex, Max; Harn, Donald; Moore-Lai, Deborah | HSPH |
| Tyrosine Sulfated antibodies against HIV-1 gp120 | Farzan, Michael Xiang, Shi-Hua | Partners/BWH |
| Hepatitis B testing and immunization in HIV+ subjects | Gandhi, Rajesh; Ukomodu, Chinweike; McGovern, Barbara; Sax, Paul; Cohen, Daniel | MGH/ BWH/ Shattuck/ Fenway |
| Development of an animal model of progressive multifocal leukoencephalopathy in nonhuman primates | Koralnik, Igor | BIDMC |
| Role of chemokine receptor binding in gp41 entry related conformational changes | Si, Zhi-hai | DFCI |
| Feasibility of rapid HIV testing of inpatients | Stone, David | Shattuck |
| Binding Stoichiometry of α- HIV-1 Neutralizing Antibodies | Yang, Xinzhen | DFCI |
 |
